The Human Proteome Project, by characterizing all 20,300 genes of the known genome, will generate the map of the protein based molecular architecture of the human body and become a resource to help elucidate biological and molecular function and advance diagnosis and treatment of diseases.

• Chromosome-based Human Proteome Project (C-HPP)
• Biology/Disease Human Proteome Project (B/D-HPP)

Overview:

The Human Proteome Project is an international project organized by the Human Proteome Organization (HUPO) that aims to revolutionize our understanding of the human proteome via a coordinated effort by many research laboratories around the world...
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Latest News:

• 2013-05-21: Spring edition of the HUPO newsletter HUPOST includes a story on the C-HPP workshop in Berlin
• 2013-01-28: Winter edition of the HUPO newsletter HUPOST includes an extensive story on the current status of the HPP
• 2013-01-01: The Chromosome-centric HUPO HPP special issue in the Journal of Proteome Research is released, including 33 new publications from the HPP.
• 2012-12-18: Master Table of Chromosome-Specific Baseline Metrics for the C-HPP to be included in articles in the special C-HPP issue of JPR (January 2013).
• 2012-10-30: Human Proteome Project Dataset Guidelines version 1.0 released for dataset deposition related to all claims of contribution to the HPP.
• 2012-08-22: Summer edition of the HUPO newsletter HUPOST begins with a story about the HPP
• 2012-07-16: Hood et al. publish "New and Improved Proteomics Technologies for Understanding Complex Biological Systems: Addressing a Grand Challenge in the Life Sciences" in Proteomics, Jul 16. doi: 10.1002/pmic.201270086. [Epub ahead of print]
• 2012-07-11: Huttenhain et al. publish "Reproducible Quantification of Cancer-associated Proteins in Body Fluids using Targeted Proteomics" in Sci Transl Med., 4(142), 142ra94
• 2012-07-03: Vidal et al. publish "The Human Proteome—a Scientific Opportunity for Transforming Diagnostics, Therapeutics, and Healthcare" in Clin Proteomics, 9(1), 6
• 2012-03-06: Progress of the HPP described in special session at the US HUPO Congress in San Francisco, California

Documents:

• 33 new publications in a special issue of the Journal of Proteome Research
• "Uniting ENCODE with genome-wide proteomics" - Paik and Hancock (2012) Nature Biotechnology, 30, 1065-7
• "Reproducible Quantification of Cancer-associated Proteins in Body Fluids using Targeted Proteomics" - Hüttenhain et al. (2012) Sci Transl Med., 4(142), 142ra94
• "New and Improved Proteomics Technologies for Understanding Complex Biological Systems: Addressing a Grand Challenge in the Life Sciences" - Hood et al. (2012) Proteomics, Jul 16. doi: 10.1002/pmic.201270086. [Epub ahead of print]
• "The Human Proteome—a Scientific Opportunity for Transforming Diagnostics, Therapeutics, and Healthcare" - Vidal et al. (2012) Clin Proteomics, 9(1), 6
• "Standard guidelines for the chromosome-centric human proteome project" - Paik et al. (2012) J Proteome Res., 11, 2005-13
• "The human proteome project: Current state and future direction" - Legrain et al., (2011) Mol Cell Proteomics, mcp.O111.009993
• "Antibody-based protein profiling of the human chromosome 21" - Uhlén et al. (2011) Mol Cell Proteomics mcp.M111.013458
• "A Chromosome-Centric Human Proteome Project to Characterize the Sets of Proteins Encoded in the Genome" - Paik et al. (2012) Nature Biotechnology, 30, 221-223

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